Exhibit 99.1

Adaptimmune Reports Second Quarter Financial Results and Business Update

Substantial progress on the afami-cel BLA including FDA agreement on plan for confirmatory evidence and favorable feedback on commercial T-cell potency assay – submission now targeted for Q4 2023

Transition of lete-cel from GSK and data from the completed pivotal trial in synovial sarcoma and MRCLS expected in late 2023

Initiated Phase 2 SURPASS-3 trial in ovarian cancer, which has the potential to be registrational and is supported by RMAT designation

Completed strategic combination with TCR² to form a pre-eminent cell therapy company adding pipeline, technologies, approximately 40 people and $84.6m in Total Liquidity¹ at closing

Company confirms pipeline data readouts over the next 18 months

Cash runway into early 2026

Webcast to be held today, August 9, 2023, at 8:00 a.m. EDT (1:00 p.m. BST)

PHILADELPHIA, PA. and OXFORD, UK, August 9, 2023 – Adaptimmune Therapeutics plc (Nasdaq: ADAP), a leader in cell therapy to treat cancer, today reported financial results for the second quarter ended June 30, 2023 and provided a business update.

Adrian Rawcliffe, Adaptimmune’s Chief Executive Officer: “The BLA submission process for afami-cel is going well with alignment with the Agency on key de-risking items. We have completed most of the wet work and we are now focused on writing and publishing the remaining sections to complete Part 3 of this submission for approval of the first engineered T-cell therapy for a solid tumor indication. We have completed the combination with TCR² and added pipeline assets, technologies, and increased our total liquidity by approximately $85m. The transition of lete-cel back from GSK is also progressing well. We have set ourselves up to make data-driven portfolio decisions to bring medicines to market that we have high conviction can make a real difference for people with cancer.”

Pipeline update and overview of near- and mid-term catalysts to make rigorous data-driven investment decisions

Adaptimmune's lead clinical franchises utilize engineered T-cell therapies targeting MAGE-A4, NY-ESO (in process of transitioning from GSK), and mesothelin, which are expressed on a broad range of solid tumors. Use of these cell therapies is supported by compelling clinical data including results in late-stage synovial sarcoma which will form the basis of the Company's first BLA submission. The Company has an enhanced "next-gen toolbox" and preclinical pipeline including PRAME and CD70 programs.

The following figure provides an overview of pipeline data catalysts that will be used to make data-driven investment decisions. To view an enhanced version of this graphic, please visit: https://images.newsfilecorp.com/files/8845/168338_adptimage.jpg. Note, this figure was previously provided in the Adaptimmune corporate deck and a press release issued on June 1^st to announce completion of the strategic combination with TCR².

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Note, the Phase 1 portion of the trial in ovarian cancer, non-small cell lung cancer (NSCLC), malignant pleural/peritoneal mesothelioma (MPM) or cholangiocarcinoma has been completed. Initial data from the Phase 1 portion of the trial was reported in September 2022. Focus was subsequently narrowed to ovarian cancer.

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More mature clinical and translational Phase 1 and 2 data will be evaluated later this year to determine next steps with gavo-cel.

TC-510: next-generation therapy targeting mesothelin

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The Phase 1/2 clinical trial for TC-510 for people with MPM, ovarian cancer, pancreatic cancer, colorectal cancer, or triple negative breast cancer is ongoing in the dose-escalation phase. Initial data readouts are anticipated this year to enable further directional decisions for TC-510.

Preclinical programs targeting PRAME and CD70 (not shown in figure)

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Adaptimmune plans to be IND-ready in late 2023 with a PRAME targeted TCR T-cell therapy. PRAME is a clinically validated target which is highly expressed across a broad range of solid tumors including breast, kidney, endometrial, ovarian, gastroesophageal, non-small cell lung, and head & neck cancers as well as melanoma. A clinical trial is expected to initiate in 2024 (indications remain to be determined).

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An IND for CD70 is planned for 2024. CD70 is expressed in hematological malignancies including acute myeloid leukemia (AML), lymphoma, and solid tumors including renal cell carcinoma.

Afami-cel: Adaptimmune plans to complete BLA submission in Q4 2023

In late 2022, Adaptimmune completed submission of the preclinical module (Part 1) of the BLA. In Q1 2023, the Company completed submission of the clinical module (Part 2). The Company is currently in the process of completing the final CMC module (Part 3).

Recently, several critical milestones have been completed:

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Demonstrated comparability of afami-cel drug batches manufactured with clinical trial supply vector and commercial supply vector

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In collaboration with our companion diagnostic (CDx) partner, completed submission to FDA of the Premarket application (PMA) for the MAGE-A4 CDx assay

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Agreed confirmatory evidence plan with FDA: Cohort 2 of the SPEARHEAD-1 trial will act as confirmatory evidence for full approval, enrollment in Cohort 2 has completed

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Completed method validation for lot release assays (including potency assays)

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Completed vector process performance qualification (PPQ)

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Initiated T-cell process performance qualification (PPQ)

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Secured favorable FDA feedback on the commercial T-cell potency assay including agreement on the proposed potency dataset for inclusion in the submission. The FDA has not requested any new or additional information on T-cell potency to precede the BLA submission.

This BLA is supported by data from Cohort 1 of the pivotal trial SPEARHEAD-1, which met its primary endpoint for efficacy. The Company has Regenerative Medicine Advanced Therapy (RMAT) designation from the FDA for afami-cel for the treatment of synovial sarcoma.

Afami-cel data presentation at ASCO 2023

Data from SPEARHEAD-1 was presented in a poster at the American Society of Clinical Oncology (ASCO) Annual Meeting, which is available HERE and summarized below.

Financial Results for the three and six months ended June 30, 2023

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Cash / liquidity position: As of June 30, 2023, Adaptimmune had cash and cash equivalents of $77.0 million and Total Liquidity¹ of $204.7 million, compared to $108.0 million and $204.6 million, respectively, as of December 31, 2022.

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Revenue: Revenue for the three and six months ended June 30, 2023, was $5.1 million and $52.7 million, respectively, compared to $5.5 million and $9.1 million for the same periods in 2022. Revenue has increased in the six months to June 30, 2023, compared to the same period in 2022 primarily due to the termination of the Astellas collaboration, resulting in the remaining deferred income for the collaboration being released as revenue in March 2023.

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Research and development (R&D) expenses: R&D expenses for the three and six months ended June 30, 2023, were $30.0 million and $55.5 million, respectively, compared to $34.7 million and $71.5 million for the same periods in 2022. R&D expenses decreased due to a decrease in the average number of employees engaged in research and development, decreases in subcontracted expenditures, a decrease in share-based compensation expenses, a decrease in in-process research and development costs and a decrease in offsetting reimbursements receivable for research and development tax and expenditure credits.

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General and administrative (G&A) expenses: G&A expenses for the three and six months ended June 30, 2023, were $20.1 million and $40.5 million, respectively, compared to $14.6 million and $31.4 million for the same periods in 2022. G&A expenses increased due to restructuring and charges recognised in the first quarter of 2023, an increase in other corporate costs due to an increase in accounting, legal and professional fees incurred in relation to the TCR² Therapeutics, Inc merger agreement and severance and other related costs for former TCR² Therapeutics leadership, offset by a decrease in share-based compensation expenses.

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Gain on bargain purchase: a $22.2 million gain on bargain purchase was recognised in the three and six months ended June 30, 2023, from the strategic combination with TCR² Therapeutics, Inc.

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Net loss: Net loss attributable to holders of the Company's ordinary shares for the three and six months ended June 30, 2023, was $21.4 million and $20.4 million, respectively ($(0.02) and $(0.02) per ordinary share), compared to $44.5 million and $94.8 million, respectively ($(0.05) and $(0.10) per ordinary share), for the same periods in 2022.

Financial Guidance

The Company believes that its existing cash, cash equivalents and marketable securities, together with the additional payments under the Strategic Collaboration and License Agreement with Genentech and payments under the Termination and Transfer Agreement with GSK, will fund the Company’s current operations into early 2026, as further detailed in the Company’s Quarterly Report on Form 10-Q for the second quarter ended June 30, 2023, to be filed with the Securities and Exchange Commission following this earnings release.

Webcast Information

The Company will host a live webcast to provide additional details at 8:00 a.m. EDT (1:00 p.m. BST) today, August 9, 2023. A live webcast of the conference call and replay can be accessed at https://www.gowebcasting.com/12658. Call in information is as follows: (800)-319-4610 (US or Canada) or +1 (416)-915-3239 (International and additional options available HERE). Callers should dial in 5-10 minutes prior to the scheduled start time and simply ask to join the Adaptimmune call.

About Adaptimmune

¹ Total liquidity is a non-GAAP financial measure, which is explained and reconciled to the most directly comparable financial measures prepared in accordance with GAAP below

Adaptimmune is a clinical-stage biopharmaceutical company focused on the development of novel cancer immunotherapy products for people with cancer. The Company’s cell therapy products have shown clinical responses in multiple solid tumor indications. Our unique T-cell platforms enable us to identify cancer targets, find and develop cell therapy candidates active against those targets, and produce therapeutic candidates for administration to patients. Adaptimmune’s cell therapy products include T-cells with genetically engineered T-cell receptors (“TCR T-cells”), TCR Fusion Construct T cells (TRuC-T cells), and HLA-independent TCRs (“HiTs”).

Forward-Looking Statements

This release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995 (PSLRA). These forward-looking statements involve certain risks and uncertainties. Such risks and uncertainties could cause our actual results to differ materially from those indicated by such forward-looking statements, and include, without limitation: the success, cost and timing of our product development activities and clinical trials and our ability to successfully advance our TCR therapeutic candidates through the regulatory and commercialization processes. For a further description of the risks and uncertainties that could cause our actual results to differ materially from those expressed in these forward-looking statements, as well as risks relating to our business in general, we refer you to our Annual Report on Form 10-K for the year ended December 31, 2022 filed with the Securities and Exchange Commission (SEC) on March 6, 2023, our Quarterly Reports on Form 10-Q, Current Reports on Form 8-K, and other filings with the SEC. The forward-looking statements contained in this press release speak only as of the date the statements were made and we do not undertake any obligation to update such forward-looking statements to reflect subsequent events or circumstances.

Total Liquidity (a non-GAAP financial measure)

Total Liquidity (a non-GAAP financial measure) is the total of cash and cash equivalents and marketable securities (available-for-sale debt securities). Each of these components appears separately in the condensed consolidated balance sheet. The U.S. GAAP financial measure most directly comparable to Total Liquidity is cash and cash equivalents as reported in the condensed consolidated financial statements, which reconciles to Total Liquidity as follows (in thousands):


	June 30,		December 31,
	2023		2022
Cash and cash equivalents	$	76,969	$	108,033
Marketable securities - available-for-sale debt securities		127,738		96,572
Total Liquidity	$	204,707	$	204,605

The Company believes that the presentation of Total Liquidity provides useful information to investors because management reviews Total Liquidity as part of its assessment of overall solvency and liquidity, financial flexibility, capital position and leverage.

Condensed Consolidated Statement of Operations

(unaudited, in thousands, except per share data)



	Three months ended				Six months ended
	June 30,				June 30,
	2023		2022		2023		2022
Revenue	$	5,130	$	5,538	$	52,731	$	9,113
Operating expenses
Research and development		(29,965)		(34,740)		(55,513)		(71,492)
General and administrative		(20,073)		(14,550)		(40,470)		(31,354)
Total operating expenses		(50,038)		(49,290)		(95,983)		(102,846)
Operating loss		(44,908)		(43,752)		(43,252)		(93,733)
Interest income		1,543		357		2,219		695
Gain on bargain purchase		22,155		—		22,155		—
Other income (expense), net		501		(655)		(170)		(643)
Loss before income tax expense		(20,709)		(44,050)		(19,048)		(93,681)
Income tax expense		(680)		(470)		(1,305)		(1,104)
Net loss attributable to ordinary shareholders	$	(21,389)	$	(44,520)	$	(20,353)	$	(94,785)

Net loss per ordinary share
Basic and diluted	$	(0.02)	$	(0.05)	$	(0.02)	$	(0.10)


Weighted average shares outstanding:
Basic and diluted		1,108,166,960		962,794,072		1,050,071,434		951,474,546

Condensed Consolidated Balance Sheets

(unaudited, in thousands, except share data)


	June 30,		December 31,
	2023		2022
Assets
Current assets
Cash and cash equivalents	$	76,969	$	108,033
Marketable securities - available-for-sale debt securities		127,738		96,572
Accounts receivable, net of allowance for expected credit losses of $0 and $0		2,970		7,435
Other current assets and prepaid expenses		54,094		43,330
Total current assets		261,771		255,370

Restricted cash		3,231		1,569
Operating lease right-of-use assets, net of accumulated amortization of $11,258 and $9,470		22,027		18,019
Property, plant and equipment, net of accumulated depreciation of $40,635 and $38,588		55,492		53,516
Intangible assets, net of accumulated amortization of $5,003 and $4,676		463		442
Total assets	$	342,984	$	328,916

Liabilities and stockholders’ equity
Current liabilities
Accounts payable	$	14,713	$	4,753
Operating lease liabilities, current		4,752		2,728
Accrued expenses and other current liabilities		25,242		31,215
Restructuring provision		—		2,285
Deferred revenue, current		31,418		23,520
Total current liabilities		76,125		64,501

Operating lease liabilities, non-current		21,590		20,349
Deferred revenue, non-current		117,257		160,892
Other liabilities, non-current		1,361		1,296
Total liabilities		216,333		247,038

Stockholders’ equity
Common stock - Ordinary shares par value £0.001, 1,702,760,280 authorized and 1,351,828,044 issued and outstanding (2022: 1,282,773,750 authorized and 987,109,890 issued and outstanding)		1,851		1,399
Additional paid in capital		1,057,547		990,656
Accumulated other comprehensive loss		(3,092)		(875)
Accumulated deficit		(929,655)		(909,302)
Total stockholders' equity		126,651		81,878

Total liabilities and stockholders’ equity	$	342,984	$	328,916

Condensed Consolidated Cash Flow Statement

(unaudited, in thousands)


	Six months ended
	June 30,
	2023		2022
Cash flows from operating activities
Net loss	$	(20,353)	$	(94,785)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation		3,824		2,728
Amortization		253		419
Gain on bargain purchase		(22,155)		—
Share-based compensation expense		5,513		10,631
Unrealized foreign exchange losses/(gains)		377		(108)
(Accretion)/amortization on available-for-sale debt securities		(633)		1,636
Other		663		585
Changes in operating assets and liabilities:
Decrease/(increase) in receivables and other operating assets		1,971		(22,898)
(Decrease)/increase in payables and other current liabilities		(8,801)		12,898
Decrease in deferred revenue		(41,704)		(6,758)
Net cash used in operating activities		(81,045)		(95,652)

Cash flows from investing activities
Acquisition of property, plant and equipment		(3,565)		(16,074)
Acquisition of intangible assets		(199)		—
Acquired upon acquisition of TCR2 Therapeutics Inc.		45,264		—
Maturity or redemption of marketable securities		76,119		97,605
Investment in marketable securities		(67,121)		(42,197)
Other		537		—
Net cash provided by investing activities		51,035		39,334

Cash flows from financing activities
Proceeds from issuance of common stock from offerings, net of commissions and issuance costs		188		9,976
Proceeds from exercise of stock options		22		36
Net cash provided by financing activities		210		10,012

Effect of currency exchange rate changes on cash, cash equivalents and restricted cash		398		(5,836)
Net decrease in cash, cash equivalents and restricted cash		(29,402)		(52,142)
Cash, cash equivalents and restricted cash at start of period		109,602		151,666
Cash, cash equivalents and restricted cash at end of period	$	80,200	$	99,524