Exhibit 99.1

Adaptimmune Reports Q2 2024 Financial and Business Updates

Adaptimmune received U.S. FDA accelerated approval of Tecelra® (afami-cel), the first approved engineered cell therapy for a solid tumor

Patients can begin treatment journey; biomarker testing available; Adaptimmune systems ready to receive orders

At the end of Q2, Adaptimmune had Total Liquidity¹ of $214.8 million

PHILADELPHIA, PA. and OXFORD, UK, August 12, 2024 – Adaptimmune Therapeutics plc (Nasdaq: ADAP), a company redefining the treatment of solid tumor cancers with cell therapy, today reports financial results and business updates for the second quarter ended June 30, 2024. The Company will host a live webcast at 8:00 a.m. EDT (1:00 p.m. BST) today.

Adrian Rawcliffe, Adaptimmune’s Chief Executive Officer: “On 1 August, we received US FDA approval for Tecelra, the first ever engineered cell therapy for a solid tumor and the first new treatment option for people with synovial sarcoma in more than a decade. We have hit the ground running to make Tecelra available to eligible patients. Patients can start their treatment journey now with healthcare providers able to begin testing and our ordering platform is up and running. Tecelra will be available in 6-10 US authorized treatment centers in the coming weeks. Tecelra is the first product in our sarcoma franchise, and we are planning to commence our rolling BLA submission for lete-cel in 2025 and commercial launch in 2026. We expect our sarcoma franchise to redefine the treatment landscape in advanced soft tissue sarcoma with projected peak US sales of $400 million.”

Sarcoma Franchise with Tecelra® and lete-cel

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U.S. Food and Drug Administration (FDA) approves Tecelra® for the treatment of advanced MAGE-A4+ synovial sarcoma in adults with certain HLA types who have received prior chemotherapy.

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Tecelra® is the first engineered cell therapy for solid tumors.

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Tecelra® is the first new treatment option for synovial sarcoma in more than a decade.

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Tecelra® is a single infusion treatment.

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No Risk Evaluation and Mitigation Strategies (REMS) program was required for BLA approval.

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Patients can start their treatment journey now, with testing approved and available in the United States.

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Sarcoma centers of excellence across the Unites States are being onboarded as Authorized Treatment Centers (ATCs) for Tecelra®.

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The approval of Tecelra® was based on results of the SPEARHEAD-1 (Cohort 1) trial. The major efficacy outcome was overall response rate (ORR) by independent review and supported by duration of response. Tecelra® treatment resulted in an ORR of 43% with a complete response rate of 4.5%. The median duration of response was 6 months (95% CI: 4.6, not reached). Among patients who were responsive to the treatment, 39.0% had a duration of response of 12 months or longer. Data from the pivotal SPEARHEAD-1 trial were previously published in The Lancet earlier this year.

¹ Total liquidity is a non-GAAP financial measure, which is explained and reconciled to the most directly comparable financial measures prepared in accordance with GAAP below

Financial Results for the three and six months ended June 30, 2024

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Cash / liquidity position: As of June 30, 2024, Adaptimmune had cash and cash equivalents of $211.8 million and Total Liquidity² of $214.8 million, compared to $144.0 million and $146.9 million respectively, as of December 31, 2023.

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Revenue: Revenue for the three and six months ended June 30, 2024, was $128.2 million and $133.9 million, respectively, compared to $5.1 million and $52.7 million for the same periods in 2023. Revenue has increased in 2024, compared to the same periods in 2023 primarily due to the termination of the Genentech collaboration in the second quarter of 2023, resulting in the majority of the remaining deferred income for the collaboration being recognized as revenue including a cumulative catch-up adjustment of $101.3 million. This was significantly higher than the impact from the termination of the Astellas collaboration in 2023, which resulted in $42.4 million of revenue being recognized in March 2023.

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Research and development (R&D) expenses: R&D expenses for the three and six months ended June 30, 2024, were $40.4 million and $75.7 million, respectively, compared to $30.0 million and $55.5 million for the same periods in 2023. R&D expenses increase due to an increase in the average number of employees engaged in research and development, increases in subcontracted expenditures, an increase in in-process research and development costs and a decrease in offsetting reimbursements receivable for research and development tax and expenditure credits.

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General and administrative (G&A) expenses: G&A expenses for the three and six months ended June 30, 2024, were $19.1 million and $38.8 million, respectively, compared to $20.1 million and $40.5 million for the same periods in 2023. G&A expenses decreased due to restructuring and charges recognised in the first quarter of 2023 that were not repeated in 2024 and an increase in offsetting reimbursements, offset by an increase in other corporate costs due to an increase in accounting, legal and professional fees in the second quarter of 2024 due to fees relating to business development work and preparation for commercialization.

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Net profit/(loss): Net profit attributable to holders of the Company's ordinary shares for the three and six months ended June 30, 2024, was $69.5 million and $21.0 million, respectively ($0.05 and $0.01 per ordinary share), compared to losses of $21.3 million and $20.4 million ($(0.02) and $(0.02) per ordinary share), for the same periods in 2023.

Today’s Webcast Details

A live webcast and replay can be accessed HERE. Call in information is as follows: +1-844-763-8274 (US or Canada) or +1-647-484-8814 (International). Callers should dial in 5-10 minutes prior to the scheduled start time and simply ask to join the Adaptimmune call.

About Adaptimmune
Adaptimmune is a fully integrated cell therapy company working to redefine how cancer is treated. With its unique engineered T cell receptor (TCR) platform, the Company is developing personalized medicines designed to target and destroy difficult-to-treat solid tumor cancers and to radically improve the patient’s cancer treatment experience.

Forward-Looking Statements
This release contains "forward-looking statements" within the meaning of the safe harbor provisions of Section 27A of the Securities Act and Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements address our expected future business, financial performance, financial condition, as well as the results of operations and often contain words such as “anticipate” “believe,”

² Total liquidity is a non-GAAP financial measure, which is explained and reconciled to the most directly comparable financial measures prepared in accordance with GAAP below

“expect,” “may,” “plan,” “potential,” “will,” and similar expressions. Such statements are based only upon current expectations of Adaptimmune. Reliance should not be placed on these forward-looking statements because they involve certain risks and uncertainties. Such risks and uncertainties could cause our actual results to differ materially from those indicated by such forward-looking statements, and include, without limitation: the success, cost and timing of our product development activities and clinical trials and our ability to successfully advance our TCR therapeutic candidates through the regulatory and commercialization processes. For a further description of the risks and uncertainties that could cause our actual results to differ materially from those expressed in these forward-looking statements, as well as risks relating to our business in general, we refer you to our Annual Report on Form 10-K filed with the Securities and Exchange Commission for the year ended December 31, 2023, our Quarterly Reports on Form 10-Q, Current Reports on Form 8-K, and other filings with the Securities and Exchange Commission. The forward-looking statements contained in this press release speak only as of the date the statements were made and we do not undertake any obligation to update such forward-looking statements to reflect subsequent events or circumstances.

Total Liquidity (a non-GAAP financial measure)

Total Liquidity (a non-GAAP financial measure) is the total of cash and cash equivalents and marketable securities (available-for-sale debt securities). Each of these components appears separately in the condensed consolidated balance sheet. The U.S. GAAP financial measure most directly comparable to Total Liquidity is cash and cash equivalents as reported in the condensed consolidated financial statements, which reconciles to Total Liquidity as follows (in thousands):


	June 30,		December 31,
	2024		2023
Cash and cash equivalents	$	211,810	$	143,991
Marketable securities - available-for-sale debt securities		2,979		2,947
Total Liquidity	$	214,789	$	146,938

The Company believes that the presentation of Total Liquidity provides useful information to investors because management reviews Total Liquidity as part of its assessment of overall solvency and liquidity, financial flexibility, capital position and leverage.

Condensed Consolidated Statement of Operations

(unaudited, in thousands, except per share data)



	Three months ended				Six months ended
	June 30,				June 30,
	2024		2023		2024		2023
Revenue	$	128,231	$	5,130	$	133,909	$	52,731
Operating expenses
Research and development		(40,448)		(29,965)		(75,655)		(55,513)
General and administrative		(19,083)		(20,073)		(38,815)		(40,470)
Total operating expenses		(59,531)		(50,038)		(114,470)		(95,983)
Operating profit/(loss)		68,700		(44,908)		19,439		(43,252)
Interest income		1,376		1,543		2,721		2,219
Interest expense		(526)		—		(526)		—
Gain on bargain purchase		—		22,155		—		22,155
Other income (expense), net		497		501		436		(170)
Profit/(loss) before income tax expense		70,047		(20,709)		22,070		(19,048)
Income tax expense		(526)		(680)		(1,052)		(1,305)
Net profit/(loss) attributable to ordinary shareholders	$	69,521	$	(21,389)	$	21,018	$	(20,353)

Net profit/(loss) per ordinary share
Basic	$	0.05	$	(0.02)	$	0.01	$	(0.02)
Diluted	$	0.04	$	(0.02)	$	0.01	$	(0.02)


Weighted average shares outstanding:
Basic		1,533,531,837		1,108,166,960		1,492,386,749		1,050,071,434
Diluted		1,559,183,774		1,108,166,960		1,519,004,675		1,050,071,434

Condensed Consolidated Balance Sheets

(unaudited, in thousands, except share data)


	June 30,		December 31,
	2024		2023
Assets
Current assets
Cash and cash equivalents	$	211,810	$	143,991
Marketable securities - available-for-sale debt securities (amortized cost of $2,979 and $2,940) net of allowance for expected credit losses of $0 and $0		2,979		2,947
Accounts receivable, net of allowance for expected credit losses of $0 and $0		2,335		821
Other current assets and prepaid expenses		36,646		59,793
Total current assets		253,770		207,552

Restricted cash		2,866		3,026
Operating lease right-of-use assets, net of accumulated amortization of $15,645 and $13,220		18,203		20,762
Property, plant and equipment, net of accumulated depreciation of $51,182 and $46,020		45,867		50,946
Intangible assets, net of accumulated amortization of $5,257 and $5,155		996		330
Total assets	$	321,702	$	282,616

Liabilities and stockholders’ equity
Current liabilities
Accounts payable	$	7,513	$	8,128
Operating lease liabilities, current		5,293		5,384
Accrued expenses and other current liabilities		30,850		30,303
Deferred revenue, current		38,417		28,973
Total current liabilities		82,073		72,788

Operating lease liabilities, non-current		17,101		19,851
Deferred revenue, non-current		99,860		149,060
Borrowings, non-current		24,954		—
Other liabilities, non-current		1,440		1,404
Total liabilities		225,428		243,103

Stockholders’ equity
Common stock - Ordinary shares par value £0.001, 2,039,252,874 authorized and 1,534,220,604 issued and outstanding (2023: 1,702,760,280 authorized and 1,363,008,102 issued and outstanding)		2,083		1,865
Additional paid in capital		1,099,758		1,064,569
Accumulated other comprehensive loss		(3,412)		(3,748)
Accumulated deficit		(1,002,155)		(1,023,173)
Total stockholders' equity		96,274		39,513

Total liabilities and stockholders’ equity	$	321,702	$	282,616

Condensed Consolidated Cash Flow Statement

(unaudited, in thousands)


	Six months ended
	June 30,
	2024		2023
Cash flows from operating activities
Net profit/(loss)	$	21,018	$	(20,353)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation		5,457		3,824
Amortization		115		253
Gain on bargain purchase		—		(22,155)
Share-based compensation expense		6,160		5,513
Unrealized foreign exchange (gains)/losses		(266)		377
Accretion on available-for-sale debt securities		(42)		(633)
Other		2		663
Changes in operating assets and liabilities:
Decrease in receivables and other operating assets		20,788		1,971
Increase/(decrease) in payables and other current liabilities		1,012		(8,801)
Increase in borrowings		454		—
Decrease in deferred revenue		(39,249)		(41,704)
Net cash provided by/(used in) operating activities		15,449		(81,045)

Cash flows from investing activities
Acquisition of property, plant and equipment		(524)		(3,565)
Acquisition of intangible assets		(588)		(199)
Cash from acquisition of TCR2 Therapeutics Inc.		—		45,264
Maturity or redemption of marketable securities		—		76,119
Investment in marketable securities		—		(67,121)
Other		11		537
Net cash (used in)/provided by investing activities		(1,101)		51,035

Cash flows from financing activities
Proceeds from issuance of borrowings, net of discount		24,500		—
Proceeds from issuance of common stock from offerings, net of commissions and issuance costs		29,171		188
Proceeds from exercise of stock options		76		22
Net cash provided by financing activities		53,747		210

Effect of currency exchange rate changes on cash, cash equivalents and restricted cash		(436)		398
Net increase/(decrease) in cash, cash equivalents and restricted cash		67,659		(29,402)
Cash, cash equivalents and restricted cash at start of period		147,017		109,602
Cash, cash equivalents and restricted cash at end of period	$	214,676	$	80,200