Quarterly report pursuant to Section 13 or 15(d)

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
 9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Cash flows from operating activities    
Net loss $ (42,875,000) $ (56,165,000)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation 3,418,000 2,290,000
Amortization 267,000 122,000
Share-based compensation expense 7,956,000 6,825,000
Unrealized foreign exchange gains (6,886,000) (1,943,000)
Other 606,000  
Changes in operating assets and liabilities:    
Increase (decrease) in receivables and other operating assets 4,180,000 (912,000)
Increase (decrease) in non-current operating assets (484,000) 2,041,000
Decrease (increase) in payables and deferred revenue 859,000 (2,796,000)
Net cash used in operating activities (32,959,000) (50,538,000)
Cash flows from investing activities    
Acquisition of property, plant and equipment (22,791,000) (4,840,000)
Acquisition of intangibles (288,000) (1,024,000)
Proceeds from disposal of property, plant and equipment 550,000  
Maturity of short-term deposits 40,645,000 49,497,000
Investment in short-term deposits (18,000,000) (42,837,000)
Maturity or redemption of marketable securities 7,032,000  
Investment in marketable securities (93,218,000)  
Net cash (used in) provided by investing activities (86,070,000) 796,000
Cash flows from financing activities    
Proceeds from issuance of common stock, after offering expenses of $4,774 103,167,000  
Proceeds from exercise of stock options 401,000  
Net cash provided by financing activities 103,568,000  
Effect of currency exchange rate changes on cash, cash equivalents and restricted cash 2,223,000 (4,443,000)
Net decrease in cash and cash equivalents (13,238,000) (54,185,000)
Cash, cash equivalents and restricted cash at start of period 162,796,000 198,771,000
Cash, cash equivalents and restricted cash at end of period $ 149,558,000 $ 144,586,000