Quarterly report pursuant to Section 13 or 15(d)

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Cash flows from operating activities    
Net loss $ (64,583,000) $ (41,997,000)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation 3,499,000 2,023,000
Amortization 304,000 159,000
Share-based compensation expense 8,411,000 4,757,000
Realized loss on available-for-sale debt securities 2,473,000  
Unrealized foreign exchange losses (gains) 2,915,000 (3,206,000)
Other 16,000 194,000
Changes in operating assets and liabilities:    
(Increase) decrease in receivables and other operating assets (11,602,000) 2,301,000
Decrease (increase) in non-current operating assets 87,000 (554,000)
Decrease in payables and deferred revenue (24,162,000) (10,125,000)
Net cash used in operating activities (82,642,000) (46,448,000)
Cash flows from investing activities    
Acquisition of property, plant and equipment (3,139,000) (21,188,000)
Acquisition of intangibles (10,000) (266,000)
Proceeds from disposal of property, plant and equipment   550,000
Maturity of short-term deposits   22,857,000
Investment in short-term deposits   (18,000,000)
Maturity or redemption of marketable securities 70,717,000  
Investment in marketable securities (33,556,000) (79,774,000)
Net cash provided by (used in) investing activities 34,012,000 (95,821,000)
Cash flows from financing activities    
Proceeds from issuance of common stock, net of issuance costs $4,774   103,167,000
Proceeds from exercise of stock options 2,424,000 31,000
Net cash provided by financing activities 2,424,000 103,198,000
Effect of currency exchange rate changes on cash, cash equivalents and restricted cash 4,417,000 2,429,000
Net decrease in cash, cash equivalents and restricted cash (41,789,000) (36,642,000)
Cash, cash equivalents and restricted cash at start of period 88,296,000 162,796,000
Cash, cash equivalents and restricted cash at end of period $ 46,507,000 $ 126,154,000