Quarterly report pursuant to Section 13 or 15(d)

Contingencies and commitments - Clinical Trials and Contract Manufacturing Commitments (Details)

v3.5.0.2
Contingencies and commitments - Clinical Trials and Contract Manufacturing Commitments (Details) - Clinical trials and contract manufacturing commitments - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2016
Jun. 30, 2015
Jun. 30, 2016
Jun. 30, 2015
Contingencies and commitments        
Other commitments $ 47,524   $ 47,524  
Other commitments, due within one year 28,810   28,810  
Other commitments, due in one to three years 11,896   11,896  
Other commitments, due in three to five years 6,818   6,818  
Subcontract costs $ 6,323 $ 2,845 $ 9,876 $ 4,633