Quarterly report pursuant to Section 13 or 15(d)

UNAUDITED CONDENSED CONSOLIDATED STATEMENT OF CHANGE IN EQUITY

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UNAUDITED CONDENSED CONSOLIDATED STATEMENT OF CHANGE IN EQUITY - USD ($)
$ in Thousands
Common stock
Additional paid in capital
Accumulated foreign currency translation adjustments
Accumulated unrealized gains (losses) on available-for-sale debt securities
Accumulated deficit
Total
Increase (Decrease) in Stockholders' Equity            
Cumulative effect of applying new accounting standards         $ 8,645 $ 8,645
Beginning balance as adjusted $ 854 $ 455,401 $ (17,867) $ (3,774) (222,985) 211,629
Beginning balance as adjusted, shares 562,119,334          
Balance at the beginning of the period at Dec. 31, 2017 $ 854 455,401 (17,867) (3,774) (231,630) 202,984
Balance at the beginning of the period, shares at Dec. 31, 2017 562,119,334          
Increase (Decrease) in Stockholders' Equity            
Net loss         (20,738) (20,738)
Issuance of shares upon exercise of stock options $ 4 1,530       1,534
Issuance of shares upon exercise of stock options (in shares) 2,740,626          
Foreign currency translation adjustments     (2,525)     (2,525)
Unrealized holding gains (losses) on available-for-sale debt securities, net of tax of $0       (4,056)   (4,056)
Reclassification from accumulated other comprehensive income of gains on available-for-sale debt securities included in net income, net of tax of $       1,163   1,163
Share-based compensation expense   4,672       4,672
Balance at the end of the period at Mar. 31, 2018 $ 858 461,603 (20,392) (6,667) (243,723) 191,679
Balance at the end of the period, shares at Mar. 31, 2018 564,859,960          
Balance at the beginning of the period at Dec. 31, 2017 $ 854 455,401 (17,867) (3,774) (231,630) 202,984
Balance at the beginning of the period, shares at Dec. 31, 2017 562,119,334          
Increase (Decrease) in Stockholders' Equity            
Net loss           (64,583)
Unrealized holding gains (losses) on available-for-sale debt securities, net of tax of $0           1,167
Balance at the end of the period at Jun. 30, 2018 $ 860 466,229 (14,285) (134) (287,568) 165,102
Balance at the end of the period, shares at Jun. 30, 2018 566,496,400          
Balance at the beginning of the period at Mar. 31, 2018 $ 858 461,603 (20,392) (6,667) (243,723) 191,679
Balance at the beginning of the period, shares at Mar. 31, 2018 564,859,960          
Increase (Decrease) in Stockholders' Equity            
Net loss         (43,845) (43,845)
Issuance of shares upon exercise of stock options $ 2 887       889
Issuance of shares upon exercise of stock options (in shares) 1,636,440          
Foreign currency translation adjustments     6,107     6,107
Unrealized holding gains (losses) on available-for-sale debt securities, net of tax of $0       5,223   5,223
Reclassification from accumulated other comprehensive income of gains on available-for-sale debt securities included in net income, net of tax of $       1,310   1,310
Share-based compensation expense   3,739       3,739
Balance at the end of the period at Jun. 30, 2018 $ 860 466,229 (14,285) (134) (287,568) 165,102
Balance at the end of the period, shares at Jun. 30, 2018 566,496,400          
Balance at the beginning of the period at Dec. 31, 2018 $ 939 574,208 (9,607) (156) (318,499) $ 246,885
Balance at the beginning of the period, shares at Dec. 31, 2018 627,454,270         627,454,270
Increase (Decrease) in Stockholders' Equity            
Net loss         (27,412) $ (27,412)
Issuance of shares upon exercise of stock options $ 1 35       36
Issuance of shares upon exercise of stock options (in shares) 840,432          
Foreign currency translation adjustments     (3,543)     (3,543)
Unrealized holding gains (losses) on available-for-sale debt securities, net of tax of $0       210   210
Share-based compensation expense   3,479       3,479
Balance at the end of the period at Mar. 31, 2019 $ 940 577,722 (13,150) 54 (345,911) 219,655
Balance at the end of the period, shares at Mar. 31, 2019 628,294,702          
Balance at the beginning of the period at Dec. 31, 2018 $ 939 574,208 (9,607) (156) (318,499) $ 246,885
Balance at the beginning of the period, shares at Dec. 31, 2018 627,454,270         627,454,270
Increase (Decrease) in Stockholders' Equity            
Net loss           $ (68,499)
Unrealized holding gains (losses) on available-for-sale debt securities, net of tax of $0           278
Balance at the end of the period at Jun. 30, 2019 $ 943 581,245 (8,308) 109 (386,998) $ 186,991
Balance at the end of the period, shares at Jun. 30, 2019 630,672,578         630,672,578
Balance at the beginning of the period at Mar. 31, 2019 $ 940 577,722 (13,150) 54 (345,911) $ 219,655
Balance at the beginning of the period, shares at Mar. 31, 2019 628,294,702          
Increase (Decrease) in Stockholders' Equity            
Net loss         (41,087) (41,087)
Issuance of shares upon exercise of stock options $ 3 327       330
Issuance of shares upon exercise of stock options (in shares) 2,377,876          
Foreign currency translation adjustments     4,842     4,842
Unrealized holding gains (losses) on available-for-sale debt securities, net of tax of $0       68   68
Reclassification from accumulated other comprehensive income of gains on available-for-sale debt securities included in net income, net of tax of $       (13)   (13)
Share-based compensation expense   3,196       3,196
Balance at the end of the period at Jun. 30, 2019 $ 943 $ 581,245 $ (8,308) $ 109 $ (386,998) $ 186,991
Balance at the end of the period, shares at Jun. 30, 2019 630,672,578         630,672,578