Adaptimmune Therapeutics plc is incorporated in England, pursuant to the laws of England and Wales. The company's registered number is 09338148.

Our headquarters are at 60 Jubilee Avenue, Milton Park, Abingdon, Oxfordshire OX14 4RX, UK. Adaptimmune also has offices in Philadelphia, PA at 351 Rouse Boulevard, Philadelphia, PA 19112.

Our financial year ends on December 31.

Our independent Registered Public Accounting firm is KPMG LLP.

Adaptimmune is listed on the NASDAQ Global Select Market under the ticker symbol “ADAP”.

Our IPO occurred in May 2015.

Adaptimmune issued new unlisted ordinary shares which are held by a custodian of Citibank N.A, a depositary bank. These ordinary shares underlie the issuance of American Depositary Receipts (ADRs) to shareholders who invested in the IPO. The ADRs are readily tradable among ADR shareholders.

An American Depositary Receipt (ADR) is a negotiable instrument that represents ownership in securities of a non-US company; it is a mechanism designed to facilitate US trading of non-US securities.

ADRs are quoted and traded in US dollars in the US securities market. Also, the dividends, if any, are paid to investors in US dollars.

An American Depositary Share (ADS) is a US dollar-denominated share, evidenced by an ADR, which represents a specified number of underlying shares held in custody in the UK.

Adaptimmune's ADSs, each representing 6 Ordinary Shares, are traded on the NASDAQ Stock Market under the ADAP symbol.

An ADR is the actual receipt that is issued by a depositary bank representing ownership of a company's underlying ordinary shares. An ADR can represent any number of ADSs. The term "ADR" is often used to mean both the receipt and the securities themselves.

Adaptimmune has a Nasdaq listed ADR programme administered by Citibank N.A and ADR enquiries may be directed to the address below:

Citibank Shareholder Services
P.O. Box 43077
Providence
Rhode Island
02940-3077
USA

Phone - toll free: 1-877-Citi-ADR (248-4237)
International: 1-781-575-4555
Email: Citibank@shareholders-online.com
Or visit Citi's Depositary Receipts Services at: www.citi.com/dr

You can buy an ADR through a broker, just as you would any other U.S. securities. Adaptimmune does not currently have a direct ADR purchase plan.

The Adaptimmune ADR share price can be found on the Nasdaq Stock Exchange site at the following link: http://www.nasdaq.com/symbol/adap

As an ADR holder on the record date, you will have the sole right to vote the equivalent number of underlying shares as represented by your Adaptimmune ADR holdings. You will receive your proxy card and other relevant documentation through your usual intermediary.

A registered holder is one whose name appears on the books of the depositary. The registered holder is considered the owner of record. A beneficial holder is one whole holdings are registered in a name other than their own, such as the name of a broker, bank or nominee account.

Please contact Citibank Shareholder Services when you move so that your account records can be updated. Citibank Shareholder Services can be at toll free: 1-877-Citi-ADR (248-4237), International: 1-781-575-4555 during Monday-Friday 08:30 AM through 6:00 PM EST. Email: Citibank@shareholders-online.com

Adaptimmune has appointed Computershare Investor Services PLC as its Registrars. The Registrars manages Adaptimmune’s ordinary share register on its behalf. They are responsible for ensuring the shareholder details are recorded accurately.

For shareholder enquiries relating to your ordinary shareholding such as changing your name, address, and shareholder certificates, please contact our Registrars by writing to:

Computershare Investor Services PLC
The Pavilions
Bridgwater Road
Bristol
BS99 6ZZ
England
Tel: +44 (0) 870 702 0003
www.investorcentre.co.uk

Please visit the news section of our website

Adaptimmune’s SEC filings can be viewed at the SEC Filings section or at the SEC’s website

For investor-related questions, please call 215-825-9306 or send an email to IR@adaptimmune.com