Quarterly report pursuant to Section 13 or 15(d)

UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

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UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
 6 Months Ended 12 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Dec. 31, 2021
Cash flows from operating activities      
Net loss $ (94,785,000) $ (76,831,000)  
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation 2,728,000 2,879,000  
Amortization 419,000    
Share-based compensation expense 10,631,000 10,783,000  
Unrealized foreign exchange gains (108,000) (267,000)  
Amortization on available-for-sale debt securities 1,636,000 2,884,000  
Other 585,000 1,401,000  
Changes in operating assets and liabilities:      
Increase in receivables and other operating assets (22,898,000) (21,457,000)  
Increase in payables and other current liabilities 12,898,000 663,000  
Decrease in deferred revenue (6,758,000) 1,946,000 $ 26,517,000
Net cash used in operating activities (95,652,000) (77,999,000)  
Cash flows from investing activities      
Acquisition of property, plant and equipment (16,074,000) (2,924,000)  
Acquisition of intangibles assets   (143,000)  
Maturity or redemption of marketable securities 97,605,000 154,465,000  
Investment in marketable securities (42,197,000) (81,958,000)  
Net cash provided by investing activities 39,334,000 69,440,000  
Cash flows from financing activities      
Proceeds from issuance of common stock from offerings, net of commissions and issuance costs 9,976,000 2,519,000  
Proceeds from exercise of stock options 36,000 578,000  
Net cash provided by financing activities 10,012,000 3,097,000  
Effect of currency exchange rate changes on cash, cash equivalents and restricted cash (5,836,000) (937,000)  
Net decrease in cash, cash equivalents and restricted cash (52,142,000) (6,399,000)  
Cash, cash equivalents and restricted cash at start of period 151,666,000 61,484,000 61,484,000
Cash, cash equivalents and restricted cash at end of period $ 99,524,000 $ 55,085,000 $ 151,666,000