Annual report pursuant to Section 13 and 15(d)

Stockholders equity - Offerings (Details)

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Stockholders equity - Offerings (Details)
2 Months Ended 12 Months Ended
Apr. 08, 2022
USD ($)
Mar. 04, 2024
USD ($)
shares
Dec. 31, 2023
USD ($)
shares
Dec. 31, 2023
£ / shares
May 30, 2023
£ / shares
Dec. 31, 2022
£ / shares
Shareholders' equity            
Nominal value of ordinary shares | £ / shares       £ 0.001   £ 0.001
Remaining amount under the Sales Agreement   $ 171,067,867        
Number of ordinary shares sold (in shares) | shares   112,500,000        
Net proceeds   $ 14,653,500        
2022 Sales Agreement            
Shareholders' equity            
Remaining amount under the Sales Agreement     $ 186,067,867      
Number of ordinary shares sold (in shares) | shares     3,854,496      
Net proceeds     $ 596,716      
2022 Sales Agreement | Maximum            
Shareholders' equity            
Aggregate offering price of ADS shares under At The Market sales agreement $ 200,000,000          
American Depository Shares (ADSs)            
Shareholders' equity            
Nominal value of ordinary shares | £ / shares         £ 0.001  
Sold shares represented by American Depositary Shares (in shares) | shares   18,750,000        
American Depository Shares (ADSs) | 2022 Sales Agreement            
Shareholders' equity            
Sold shares represented by American Depositary Shares (in shares) | shares     642,416