Quarterly report pursuant to Section 13 or 15(d)

Contingencies and commitments - Clinical Trials and Contract Manufacturing Commitments (Details)

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Contingencies and commitments - Clinical Trials and Contract Manufacturing Commitments (Details) - Clinical trials and contract manufacturing commitments - USD ($)
$ in Thousands
6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Contingencies and commitments    
Other commitments $ 59,796  
Other commitments, due within one year 22,119  
Other commitments, due in one to three years 25,237  
Other commitments, due in three to five years 11,384  
Other commitments, due after five years 1,056  
Subcontract costs $ 17,295 $ 9,876