Quarterly report pursuant to Section 13 or 15(d)

Contingencies and commitments - Clinical Trials and Contract Manufacturing Commitments (Details)

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Contingencies and commitments - Clinical Trials and Contract Manufacturing Commitments (Details) - Clinical trials and contract manufacturing commitments - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Contingencies and commitments    
Other commitments $ 68,278  
Other commitments, due within one year 42,964  
Other commitments, due in one to three years 18,846  
Other commitments, due in three to five years 5,240  
Other commitments, due after five years 1,228  
Subcontract costs $ 7,705 $ 3,553