Annual report pursuant to Section 13 and 15(d)

Contingencies and commitments - Clinical Trials and Contract Manufacturing Commitments (Details)

v3.20.4
Contingencies and commitments - Clinical Trials and Contract Manufacturing Commitments (Details) - Clinical trials and contract manufacturing commitments - USD ($)
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Contingencies and commitments      
Subcontract costs $ 33,744,000 $ 32,788,000 $ 41,580,000
Other commitments 9,084,000    
Other commitments, due within one year 4,133,000    
Other commitments, due in one to three years $ 4,951,000    
Minimum      
Contingencies and commitments      
Period in which commitments will be expected to incur (in years) 1 year    
Maximum      
Contingencies and commitments      
Period in which commitments will be expected to incur (in years) 3 years