Annual report [Section 13 and 15(d), not S-K Item 405]

CONDENSED CONSOLIDATED STATEMENTS OF CHANGE IN EQUITY

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CONDENSED CONSOLIDATED STATEMENTS OF CHANGE IN EQUITY - USD ($)
$ in Thousands
Common stock
Additional paid in capital
Accumulated other comprehensive (loss) income
Accumulated deficit
Total
Balance at the beginning of the period, shares at Dec. 31, 2021 937,547,934        
Balance at the beginning of the period at Dec. 31, 2021 $ 1,337 $ 959,611 $ (11,142) $ (743,846) $ 205,960
Increase (Decrease) in Stockholders' Equity          
Issuance of shares upon exercise of stock options $ 8 42     $ 50
Issuance of shares upon exercise of stock options (in shares) 5,823,534       5,823,534
Issue of shares under At The Market sales agreement, net of commission and expenses $ 54 12,763     $ 12,817
Issue of shares under At The Market sales agreement, net of commission and expenses (in shares) 43,738,422        
Other comprehensive income (loss)     10,267   10,267
Share-based compensation expense   18,240     18,240
Net loss       (165,456) (165,456)
Balance at the end of the period at Dec. 31, 2022 $ 1,399 990,656 (875) (909,302) 81,878
Balance at the end of the period, shares at Dec. 31, 2022 987,109,890        
Increase (Decrease) in Stockholders' Equity          
Issuance of shares upon exercise of stock options $ 18 238     $ 256
Issuance of shares upon exercise of stock options (in shares) 14,614,410       14,614,410
Issue of shares under At The Market sales agreement, net of commission and expenses $ 5 619     $ 624
Issue of shares under At The Market sales agreement, net of commission and expenses (in shares) 3,854,496        
Issuance of shares upon acquisition of TCR2 $ 443 60,320     60,763
Issuance of shares upon acquisition of TCR2 (in shares) 357,429,306        
Other comprehensive income (loss)     (2,873)   (2,873)
Share-based compensation expense   12,736     12,736
Net loss       (113,871) (113,871)
Balance at the end of the period at Dec. 31, 2023 $ 1,865 1,064,569 (3,748) (1,023,173) $ 39,513
Balance at the end of the period, shares at Dec. 31, 2023 1,363,008,102       1,363,008,102
Increase (Decrease) in Stockholders' Equity          
Issuance of shares upon exercise of stock options $ 11 66     $ 77
Issuance of shares upon exercise of stock options (in shares) 8,976,462       8,976,462
Issue of shares under At The Market sales agreement, net of commission and expenses $ 209 28,963     $ 29,172
Issue of shares under At The Market sales agreement, net of commission and expenses (in shares) 163,669,056        
Other comprehensive income (loss)     1,846   1,846
Share-based compensation expense   12,055     12,055
Net loss       (70,814) (70,814)
Balance at the end of the period at Dec. 31, 2024 $ 2,085 $ 1,105,653 $ (1,902) $ (1,093,987) $ 11,849
Balance at the end of the period, shares at Dec. 31, 2024 1,535,653,620       1,535,653,620