Annual report pursuant to Section 13 and 15(d)

Contingencies and commitments - Clinical Trials and Contract Manufacturing Commitments (Details)

v3.22.4
Contingencies and commitments - Clinical Trials and Contract Manufacturing Commitments (Details) - Clinical trials and contract manufacturing commitments - USD ($)
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Contingencies and commitments      
Subcontract costs $ 54,689,000 $ 46,469,000 $ 33,744,000
Other commitments, due within one year 10,662,000    
Other commitments, due in one to three years 133,000    
Other commitments, due in three to five years 133,000    
Maximum      
Contingencies and commitments      
Other commitments $ 10,928,000