Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENTS OF OPERATIONS

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CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Revenue $ 59,505 $ 37,833 $ 14,198
Operating expenses      
Research and development (98,269) (87,388) (63,789)
General and administrative (43,601) (31,106) (23,208)
Total operating expenses (including purchases from related parties, net of reimbursements of $-, $786, $2,067) (141,870) (118,494) (86,997)
Operating loss (82,365) (80,661) (72,799)
Interest income 2,849 2,230 1,110
Other (expense) income, net (15,501) 8,744 1,002
Loss before income taxes (95,017) (69,687) (70,687)
Income taxes (497) (451) (892)
Net loss (95,514) (70,138) (71,579)
Net loss attributable to ordinary shareholders $ (95,514) $ (70,138) $ (71,579)
Net loss per ordinary share - Basic and diluted      
Basic and diluted (in dollars per share) $ (0.16) $ (0.13) $ (0.17)
Weighted average shares outstanding:      
Basic and diluted (in shares) 584,338,942 527,637,086 424,713,997
Development revenue      
Revenue $ 20,391 $ 37,833 $ 14,198
License revenue      
Revenue $ 39,114