Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENTS OF CHANGES IN EQUITY

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CONSOLIDATED STATEMENTS OF CHANGES IN EQUITY - USD ($)
$ in Thousands
Common stock
Additional paid in capital
Accumulated foreign currency translation adjustments
Accumulated unrealized gains (losses) on available-for-sale debt securities
Accumulated deficit
Total
Balance at the beginning of the period at Dec. 31, 2015 $ 682 $ 332,363 $ (8,139)   $ (89,913) $ 234,993
Balance at the beginning of the period, shares at Dec. 31, 2015 424,711,900          
Increase (Decrease) in Stockholders' Equity            
Issuance of shares upon exercise of stock options $ 1 16       $ 17
Issuance of shares upon exercise of stock options (in shares) 63,192         63,192
Other comprehensive loss before reclassifications            
Foreign currency translation adjustments     (6,110)     $ (6,110)
Net loss         (71,579) (71,579)
Share-based compensation expense   8,821       8,821
Balance at the end of the period at Dec. 31, 2016 $ 683 341,200 (14,249)   (161,492) 166,142
Balance at the end of the period, shares at Dec. 31, 2016 424,775,092          
Increase (Decrease) in Stockholders' Equity            
Cumulative effect of applying new accounting standards         8,645 8,645
Issuance of shares upon exercise of stock options $ 1 400       $ 401
Issuance of shares upon exercise of stock options (in shares) 1,142,904         1,142,904
Issuance of common stock $ 170 102,997       $ 103,167
Issuance of common stock (in shares) 136,201,338          
Other comprehensive loss before reclassifications            
Foreign currency translation adjustments     (3,618)     (3,618)
Unrealized holding losses on available-for-sale debt securities, net of tax of $0       $ (4,420)   (4,420)
Reclassification from accumulated other comprehensive income of losses on available-for-sale debt securities included in net income, net of tax of $0       646   646
Net loss         (70,138) (70,138)
Share-based compensation expense   10,804       10,804
Balance at the end of the period at Dec. 31, 2017 $ 854 455,401 (17,867) (3,774) (231,630) $ 202,984
Balance at the end of the period, shares at Dec. 31, 2017 562,119,334         562,119,334
Increase (Decrease) in Stockholders' Equity            
Beginning balance as adjusted $ 854 455,401 (17,867) (3,774) (222,985) $ 211,629
Issuance of shares upon completion of registered direct offering $ 78 99,575       99,653
Issuance of shares upon completion of registered direct offering (in shares) 60,000,000          
Issuance of shares upon exercise of stock options $ 7 3,030       $ 3,037
Issuance of shares upon exercise of stock options (in shares) 5,334,936         5,334,936
Other comprehensive loss before reclassifications            
Foreign currency translation adjustments     8,260     $ 8,260
Unrealized holding losses on available-for-sale debt securities, net of tax of $0       1,145   1,145
Reclassification from accumulated other comprehensive income of losses on available-for-sale debt securities included in net income, net of tax of $0       2,473   2,473
Net loss         (95,514) (95,514)
Share-based compensation expense   16,202       16,202
Balance at the end of the period at Dec. 31, 2018 $ 939 $ 574,208 $ (9,607) $ (156) $ (318,499) $ 246,885
Balance at the end of the period, shares at Dec. 31, 2018 627,454,270         627,454,270