Annual report pursuant to Section 13 and 15(d)

Contingencies and commitments - Clinical Trials and Contract Manufacturing Commitments (Details)

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Contingencies and commitments - Clinical Trials and Contract Manufacturing Commitments (Details) - USD ($)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Contingencies and commitments      
Subcontract costs $ 41,580,000 $ 41,505,000 $ 23,565,000
Clinical trials and contract manufacturing commitments      
Contingencies and commitments      
Other commitments 25,849,000    
Other commitments, due within one year 13,213,000    
Other commitments, due in one to three years 12,636,000    
Subcontract costs $ 4,158,000,041,505,000