Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENTS OF CASH FLOWS

v3.10.0.1
CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Cash flows from operating activities      
Net loss $ (95,514,000) $ (70,138,000) $ (71,579,000)
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation 7,188,000 5,032,000 3,126,000
Amortization 622,000 391,000 160,000
Share-based compensation expense 16,202,000 10,804,000 8,821,000
Realized loss on available-for-sale debt securities 2,473,000 646,000  
Unrealized foreign exchange losses (gains) 9,747,000 (8,599,000) (1,314,000)
Other 237,000 341,000 122,000
Changes in operating assets and liabilities:      
Increase in receivables and other operating assets (5,162,000) (7,346,000) (6,533,000)
Decrease in non-current operating assets 742,000 2,115,000 2,221,000
(Decrease) increase in payables and deferred revenue (40,923,000) 12,439,000 16,808,000
Net cash used in operating activities (104,388,000) (54,315,000) (48,168,000)
Cash flows from investing activities      
Acquisition of property, plant and equipment (3,910,000) (24,643,000) (11,506,000)
Acquisition of intangibles (798,000) (369,000) (1,279,000)
Proceeds from disposal of property, plant and equipment   550,000  
Maturity of short-term deposits   40,625,000 73,377,000
Investment in short-term deposits   (18,000,000) (42,837,000)
Maturity or redemption of marketable securities 138,038,000 29,090,000  
Investment in marketable securities (150,787,000) (153,334,000)  
Net cash (used in) provided by investing activities (17,457,000) (126,081,000) 17,755,000
Cash flows from financing activities      
Proceeds from issuance of common stock, net of issuance costs $347 and $4,774 99,653,000 103,167,000  
Proceeds from exercise of stock options 3,037,000 401,000 17,000
Net cash provided by financing activities 102,690,000 103,568,000 17,000
Effect of currency exchange rate changes on cash, cash equivalents and restricted cash 3,335,000 2,328,000 (5,579,000)
Net decrease in cash and cash equivalents (15,820,000) (74,500,000) (35,975,000)
Cash, cash equivalents and restricted cash at start of period 88,296,000 162,796,000 198,771,000
Cash, cash equivalents and restricted cash at end of period 72,476,000 88,296,000 162,796,000
Supplemental cash flow information      
Interest received 3,114,000 1,784,000 1,191,000
Income taxes paid $ 258,000 $ 1,565,000 34,000
Allowance for tenant improvements     $ 2,607,000